Boskey AL, Donnelly E, Kinnett JG. (2011) Bone quality: From bench to bedside: Opening editorial comment. Clin Orthop Relat Res 469: 2087-2089.



The term ‘‘bone quality’’ is frequently used by clinicians,
basic scientists, and engineers. However, do they mean the
same thing? In this symposium, we asked the authors what
they meant by ‘‘bone quality,’’ and as the reader will discover,
there are many aspects of bone quality that vary in
importance and scope with the person providing the definition.
In recent years, numerous reviews have explored
and described bone quality (eg, [2–25, 29]) and some have
discussed therapies for fragility fractures [13], but none has
emphasized the transition from the bench to the bedside
(and the operating room). In fact, the majority of these
reviews of bone quality are either engineering or basic
bone biology articles [3–6, 10, 11, 16], including imaging
techniques [3, 8, 12, 17, 20, 25], or papers on how to treat
osteoporosis [5, 7, 9, 15, 18, 19, 21, 23, 24]. Here too we
review those topics, providing recent research data from
leaders in the field. This symposium reviews and makes
suggestions for appropriate management of individuals
with impaired bone quality because the orthopaedic surgeon
sees cases where the quality of the bone is abnormal,
whether in patients with osteoporosis, osteopetrosis, cancer
[14], or a metabolic problem, such as diabetes [22], kidney
disease [29], or rheumatoid arthritis, and because little
guidance is available on pre- and postsurgical management
of these cases.