Lloyd receives 2014 ASBMR Young Investigator Award

The American Society for Bone and Mineral Research has awarded PhD student Ashley Lloyd a 2014 Young Investigator Award for her abstract “Cortical Tissue from Postmenopausal Women with Atypical Fractures Shows Reduced Heterogeneity in Nanomechanical Properties.” She will accept the award at the ASBMR Annual Meeting in Houston, TX September 11-15 2014.

Lloyd selected to participate in EFF/ASBMR Eighth Fellows Forum on Metabolic Bone Diseases

PhD student Ashley Lloyd was selected to participate in the Endocrine Fellows Foundation/American Society for Bone and Mineral Research (ASBMR) Eighth Fellows Forum on Metabolic Bone Diseases. She will attend the forum prior to the 2014 ASBMR annual meeting at the at the Hilton Americas Houston, Houston, TX, September 10-11, 2014.

Donnelly E, Saleh A, Unnanuntana A, Lane JM. Atypical femoral fractures: epidemiology, etiology, and patient management. Curr Opin Support Palliat Care. 2012.


Purpose of review: To review the definition, epidemiology, and putative pathophysiology of atypical femoral fractures and propose strategies for the management of patients with atypical fractures as well as patients on long-term bisphosphonates without atypical fractures.

Recent findings: Recent epidemiologic evidence shows that the absolute incidence of atypical femoral fractures is small compared with the incidence of typical hip fractures. However, long-term bisphosphonate use may be an important risk factor for atypical fractures, and minimal additional antifracture benefit has been demonstrated for treatment durations longer than 5 years for patients with postmenopausal osteoporosis. This review gives advice to aid clinicians in the management of patients with incipient or complete atypical fractures.

Summary: Extremely limited evidence is available for how best to manage patients with atypical fractures. A comprehensive metabolic approach for the management of patients on long-term bisphosphonates will help to prevent oversuppression of bone remodeling that is implicated in the pathogenesis of these fractures.

PMID: 22643705

Donnelly awarded ASBMR Junior Faculty Osteoporosis Research Award

The American Society for Bone and Mineral Research has awarded Prof. Donnelly the 2012 Junior Faculty Osteoporosis Research (JFOR) Award to support her proposal, “Spectroscopic and Biochemical Markers of Bone Quality in Patients with Atypical Femoral Fractures.” She will accept the award at the ASBMR annual meeting on 14 October 2012.

Donnelly E, Meredith DS, Nguyen JT, Gladnick BP, Rebolledo BJ, Shaffer AD, Lorich DM, Lane JM, and Boskey AL. Reduced bone tissue compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures. J Bone Miner Res.



Reduction of bone turnover with bisphosphonate treatment alters bone mineral and matrix properties. Our objective was to investigate the effect of bisphosphonate treatment on bone tissue properties near fragility fracture sites in the proximal femur in postmenopausal women with osteoporosis. The mineral and collagen properties of cortico-cancellous biopsies from the proximal femur were compared in bisphosphonate-naive (-BIS, n = 20) and bisphosphonate-treated (+BIS, n = 20, duration 7 ± 5 y) patients with intertrochanteric (IT) and subtrochanteric (ST) fractures using Fourier transform infrared imaging (FTIRI). The mean values of the FTIRI parameter distributions were similar across groups, but the widths of the parameter distributions tended to be reduced in the +BIS group relative to the -BIS group. Specifically, the distribution widths of the cortical collagen maturity and crystallinity were reduced in the +BIS group relative to those of the -BIS group by 28% (+BIS 0.45 ± 0.18 vs. -BIS 0.63 ± 0.28, p = 0.03) and 17% (+BIS 0.087 ± 0.012 vs. -BIS 0.104 ± 0.036, p = 0.05), respectively. When the tissue properties were examined as a function of fracture morphology within the +BIS group, the FTIR parameters were generally similar regardless of fracture morphology. However, the cortical mineral:matrix ratio was 8% greater in tissue from patients with atypical ST fractures (n =6) than that of patients with typical (IT or spiral ST) fractures (n = 14) (Atypical 5.6 ± 0.3 vs. Typical 5.2 ± 0.5, p = 0.03). Thus, although the mean values of the FTIR properties were similar in both groups, the tissue in bisphosphonate-treated patients had a more uniform composition than that of bisphosphonate-naïve patients. The observed reductions in mineral and matrix heterogeneity may diminish tissue-level toughening mechanisms. © 2011 American Society for Bone and Mineral Research


Fourier transform infrared imaging; cortical bone; material properties; hip fracture; atypical subtrochanteric fracture